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To study the effect of thyroxine medication on muscle function in those with full blown hypothyroidism (low thyroid hormones)

The effect of thyroxine replacement on muscle function in overt Primary Hypothyroidism

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/07/043970
Enrollment
150
Registered
2022-07-13
Start date
Unknown
Completion date
Unknown
Last updated
2022-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E039- Hypothyroidism, unspecified

Interventions

Intervention1: Thyroxine replacement: Parameters are studied before and after thyroxine replacement Intervention2: Thyroxine replacement: Hand grip strength, physical performance, CK and LDH 3 months

Sponsors

Learning resource Allowance self from Institution
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Those with TSH > 15 miu/l and either low or normal T4.

Exclusion criteria

Exclusion criteria: Those with Muscular disorders, Connective tissue disorders, hepatic, cardiac and renal disorders, orthopedic disorders.

Design outcomes

Primary

MeasureTime frame
Hand grip strength and physical performance before and after thyroxine replacementTimepoint: Baseline and 3 months after Thyroxine replacement.—

Secondary

MeasureTime frame
change in CK and LDH after thyroxine replacementTimepoint: Three after thyroxine replacement—

Countries

India

Contacts

Public ContactKishore Kumar Katam

All India Institute of Medical Sciences, Mangalagiri

katamkk@aiimsmangalagiri.edu.in9550697954

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026