Health Condition 1: K77- Liver disorders in diseases classified elsewhere
Conditions
Interventions
Intervention1: Endoscopic
Ultrasound guided Liver Biopsy: EUS will be done in the left lateral position after sedation with midazolam using a
linear echoendoscope (GF-UCT180, Olympus Asia Pacific, Tok
Sponsors
Dr Praveer Rai
Eligibility
Inclusion criteria
Inclusion criteria: 1.Adult Patients (Age >18 years) where liver biopsy is indicated 2.Those having coagulopathy or thrombocytopenia Coagulopathy is defined as INR >1.5 Thrombocytopenia is defined as Platelet count less than 1 lac/mm3
Exclusion criteria
Exclusion criteria: 1.Age 2.Pregnancy (confirmed with Standard of Care urine pregnancy test for all women with child-bearing potential only) 3.Inability to obtain Consent 4.Patient with INR >2.5 5.Patient with Platelet count below 30000/mm3 6. Patients with known malignancy precluding liver biopsy 7.Patient with Sepsis 8.Patient diagnosed with Acute liver Failure 9.Patient with diagnosis of Obstructive Jaundice 10.Patient on Anticoagulation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Outcomes; â?? Specimen quality for histological diagnosis in coagulopathy patient â?? Specimen quality for histological diagnosis: Defined as histological diagnosis could be made based on the amount of tissue obtained in needle. â?? Portal Tract number: number of Complete Portal Tracts (CPTs) â?? Specimen length: Total Sample Length (TSL) and Longest sample Length (LSL)Timepoint: 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events; 1.Bleeding-not requiring blood transfusion 2.Pain Pain will be recorded using visual analogue scale(VAS) Severe adverse effects: 1. Requiring Prolonged Hospitalisation 2. Requiring Intervention to stop Bleeding 3. Requiring blood transfusion 4. DeathTimepoint: 1 year | — |
Countries
India
Contacts
Public ContactDr Mayank
SGPGIMS Lucknow
Outcome results
None listed