Health Condition 1: 8- Other Procedures Health Condition 2: J969- Respiratory failure, unspecified
Conditions
Interventions
Intervention1: Arm Vasopressor (VP): Patients in this group will receive norepinephrine infusion at a dose of 0.08 μg/kg/min over 10 minutes prior and 5 minutes after tracheal intubation
Control Inte
Sponsors
Tata Memorial Hospital
Not Any
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adult patients (>= 18 years old) 2. Critically ill patients needing emergent tracheal intubation in ICU
Exclusion criteria
Exclusion criteria: 1.Tracheal intubation performed in the out-of-ICU/hospital setting 2.Tracheal intubation during cardiac arrest. 3.Patients with age 4.Elective tracheal intubation(for e.g for diagnostic/surgical procedures) 5.Patients on vasoactive medications at the time of screening 6.Hypotension (SBP 7.Hypertension(SBP >140)at screening 8.Urgency of tracheal intubation precludes performance of study procedures 9.Operator feels administration of a fluid bolus vasopressor is strongly indicated or contraindicated 10.Inability to obtain consent from the surrogate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiovascular collapse define by 1. decrease in systolic blood pressure (SBP) to less than 90 mm Hg or a decrease in mean arterial pressure to less than 65 mm Hg, 2.cariac arrest between induction, 3.Death between induction and 1 hour after tracheal intubation Timepoint: at 5 min and 1hrs after tracheal intubation | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical outcomes define by SBP less than 90 mm Hg or a MAP to less than 65 mm Hg, Cardiac arrest, Death, Lowest SBP, Ventilator-free days, ICU-free days, Vasopressor free days, Need for Renal Replacement therapy, ICU Mortality, Hospital Mortality, 28 Day Mortality Timepoint: at 5 min, 24 hrs and day 28 after intubation;Process measures define as Initiation of an intravenous fluid boluses, Need for vasopressors, Time for successful tracheal intubation, Incidence of successful tracheal intubation on the first laryngoscopy attempt, Number of laryngoscopy attempts, Cormack-Lehane grade of glottic view on first attempt, Need for additional airway equipment or a second operator Timepoint: at 5 min, 24 hrs and day 28 after intubation;Safety outcomes define by Lowest arterial oxygen saturation, Incidence of hypoxaemia (oxygen saturation 90%), Incidence of severe hypoxaemia (oxygen saturation 80%), Incidence of hypertension (SBP 140), Oxygen saturation, Fraction of inspired oxygen, Pao2 /FiO2 ratio Timepoint: at 5 min, 24 hrs and day 28 after intubation | — |
Countries
India
Contacts
Public ContactDr Sheila N Myatra
Tata Memorial Hospital
Outcome results
None listed