Health Condition 1: G998- Other specified disorders of nervous system in diseases classified elsewhere
Conditions
Interventions
Intervention1: Ketogenic Diet: Ketogenic Diet will be administered to children fulfilling the inclusion criteria who have failed atleast two antiseizure medications and steroids
Intervention2: Ketogen
Sponsors
PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: 1. Children aged 2-16 years of either sex with ESES refractory to at least two antiseizure medications and corticosteroids.
Exclusion criteria
Exclusion criteria: 1. Any child with EEG not consistent with ESES ( 2. Children with ESES >50% SWI in slow wave sleep who become seizure-free with 2 antiseizure medications and corticosteroids 3. Children with ESES >50% SWI in slow wave sleep who take KD for less than one-week duration 4. Decline of consent by parent/guardian 5. Children with active or past history of hyperlipidemia and /or renal calculi, pancreatitis, liver failure, suspected or proven disorders of fat metabolism, primary carnitine deficiency, carnitine palmitoyl transferase deficiency, carnitine translocase deficiency, porphyrias, or pyruvate kinase deficiency
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Percentage change in SWI in EEG at 12 weeks of KD Timepoint: 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Percentage reduction in Seizure burden at 4, 12 and 24 weeks of KD 2. Percentage change in SWI in EEG at 24 weeks of KD 3. Improvement in Cognition , Behaviour and Language at 24 weeks of KD. Timepoint: 24 weeks | — |
Countries
India
Contacts
Public ContactDr Arushi Saini
Advanced Pediatrics Centre , PGIMER , Chandigarh
Outcome results
None listed