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Effect of three concentrations of oxygen used during operation on immunity in patient undergoing surgery for benign thyroid – An experimental study

Effect Of Three Intraoperative Fractional Inspired Oxygen Concentrations On Perioperative Cell Mediated Immunity In Patients Undergoing Benign Thyroid Surgery - a Randomized Controlled Trial.

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/07/043909
Enrollment
90
Registered
2022-07-11
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D34- Benign neoplasm of thyroid gland

Interventions

Intervention1: Fractional inspired oxygen concentration of oxygen of 0.5: Group_0.5 will receive 50% oxygen from induction of general anaesthesia to the extubation of the trachea Intervention2: Fracti

Sponsors

Department of Health Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion criteria 1.ASA I, II patients, 2.Body mass index between 18-30 kg/m2, 3.Patients posted for surgery for benign thyroid conditions will be included in this study.

Exclusion criteria

Exclusion criteria: Exclusion criteria 1.Patients refusal to participate in the study, 2.Perioperative blood transfusions, 3.Chronic opioid use, 4.Renal failure, 5.Liver failure, 6.Congestive heart failure and 7.Hematological diseases will be excluded from the study.

Design outcomes

Primary

MeasureTime frame
The primary end point of the study will be effect of different FiO2 on NK cell count (CD56, CD6)Timepoint: Perioperative—

Secondary

MeasureTime frame
The secondary end points will be effect of different FiO2 on a. The total T lymphocyte count and counts for the T lymphocyte subpopulations, CD3, CD4, CD8, CD19, Th1 and Th2cells. b. Postoperative complications in patients undergoing surgery for thyroid surgeries. Timepoint: Perioperative—

Countries

India

Contacts

Public ContactIndira Gurajala

Nizams Institute of Medical Sciences

indiradevraj@yahoo.co.in7729932044

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026