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To study whether three concentrations of oxygen used during operation will affect the ability to fight infections in patients undergoing surgery for cancer of breast – An experimental study

Effect Of Three Intraoperative Fractional Inspired Oxygen Concentrations On Perioperative Cell Mediated Immunity In Patients Undergoing Surgery For Breast Cancer - A Randomized Controlled Trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/07/043849
Enrollment
90
Registered
2022-07-08
Start date
Unknown
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group_0.5: Group_0.5 will receive 50 % oxygen during general anaesthesia for surgery for Ca Breast from the time of induction of anaesthesia to end of surgery and recovery from anaesthe

Sponsors

Department of Health Research
Lead Sponsor
Department of Health Research
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: ASA I, II patients of either sex between the ages of 18-70 years, having a body mass index between 18-30 kg/m2 and posted for surgery for Ca breast will be included in this study.

Exclusion criteria

Exclusion criteria: Patients receiving preoperative chemotherapy, refusal to participate in the study, perioperative blood transfusions, chronic opioid use renal failure, liver failure, congestive heart failure and co-morbid hematological diseases will be excluded from the study.

Design outcomes

Primary

MeasureTime frame
To determine the effect of different FiO2 used intraoperatively on perioperative cell mediated immunity in patients undergoing surgery for carcinoma breast.Timepoint: Perioperative period—

Secondary

MeasureTime frame
The secondary end points will be effect of different FiO2 on a.The total T lymphocyte count and counts for the T lymphocyte subpopulations, CD3, CD4, CD8, CD19, Th1 and Th2cells. b.Postoperative complications in patients undergoing surgery for carcinoma breast.Timepoint: Duration of hospital saty—

Countries

India

Contacts

Public ContactIndira Gurajala

Nizams Institute of Medical Sciences

indiradevraj@yahoo.co.in7729932044

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026