Health Condition 1: K859- Acute pancreatitis, unspecified Health Condition 2: K509- Crohns disease, unspecified Health Condition 3: K839- Disease of biliary tract, unspecified Health Condition 4: K869- Disease of pancreas, unspecified Health Condition 5: K740- Hepatic fibrosis Health Condition 6: K519- Ulcerative colitis, unspecified
Conditions
Interventions
Intervention1: Fecal microbiota transplantation: Involves colonoscppic insertion of feces from donors into patients
Intervention2: Fecal microbiota transplantation: Involves colonoscopic insertion of
Sponsors
Department of Health Research
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged 18-75 years Patients positive for target MDR organisms by culture-based tests, at the time of discharge. No clinical evidence of active infection, Patients who agree for FMT and subsequent follow-up. Able to provide informed consent
Exclusion criteria
Exclusion criteria: Patients on concomitant antibiotics or likely to receive at the time of FMT Patients who are immunocompromised (post bone marrow transplant, solid organ transplant recipients, HIV positive patients with CD4 count Patients unable to undergo colonoscopy due to comorbidity Cirrhosis with CTP score more than or equal to 9 Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection of MDR organism in stool at 4 weeks after FMT or standard medical treatmentTimepoint: 4 weeks or prior, as indicated | — |
Secondary
| Measure | Time frame |
|---|---|
| Detection of change in stool microbiota after FMT Timepoint: 4 weeks or prior, as indicated;Detection of change in stool virome after FMT Timepoint: 4 weeks or prior, as indicated;Occurrence of any adverse eventTimepoint: 4 weeks or prior, as indicated;Infection with MDR organism Timepoint: 4 weeks or prior, as indicated;Need for antibiotics Timepoint: 4 weeks or prior, as indicated | — |
Countries
India
Contacts
Public ContactDr Vineet Ahuja
All India Institute of Medical Sciences
Outcome results
None listed