Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Intravenous Dexmedetomidine: 1 mcg/kilogram body weight administered over 10 minutes prior to administration of anaesthesia.
Control Intervention1: Nebulised Dexmedetomidine: 1 mcg/kilo
Sponsors
Shri Ram Murti Smarak Institute of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged 18-60 years of either sex , ASA physical status I/II , Duration surgical procedures Undergoing short (parotidectomy, thyroidectomy, dental extractions, laparoscopic cholecystectomy) extending up to 2 hours will be enrolled in the study. (Duration of surgery was decided based upon the elimination half-life of the shorter acting of the two drugs involved in the study, in this case being dexmedetomidine (Elimination t1/2 -2 hrs))
Exclusion criteria
Exclusion criteria: Patient refusal, Hypersensitivity to the drugs being evaluated, History of pre-operative sore throat, Upper respiratory tract infection, Pregnancy, Chronic obstructive pulmonary disease/ Asthmatic patients, Cardiac patients, Hepatic/renal disease, Mallampatti grade >2, Body Mass Index (BMI) more than 40 kg/m2, Predicted difficult airway or unanticipated difficult intubation and those requiring laryngoscopy more than 15 secs or two attempts or more, Chronic use of opioids/opioid addiction, steroids, Inability to comprehend postoperatively neuropsychiatric disorders, Preoperative drugs that could be potential confounders (clonidine, gabapentin, pregabalin and steroids) The enlisted patients, who needed more than one intubation attempt or developed any intra-operative or post-operative complication included unanticipated change in surgical plan or increase in the duration of surgery were also excluded from further evaluation and analysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in heart rate, mean arterial pressures upon laryngoscopy and intubation as compared to pre laryngoscopy/ intubation and baseline levelsTimepoint: 0, 1min, 3 min, 5 min, 7 min, 10 min, 15 min, 30min, 45 min, 60 min, 75 min, 90 min, 105 min, 120 min | — |
Secondary
| Measure | Time frame |
|---|---|
| Compare effects of these routes on intraoperative analgesic consumption and incidence and sore throat post operativelyTimepoint: Post extubation, 1 hr, 2 hr, 4 hr, 6 hr, 8 hr, 12 hr, 24 hr | — |
Countries
India
Contacts
Public ContactDr Vishwadeep Singh
SHRI RAM MURTI SMARAK INSTITUTE OF MEDICINE SCIENCES
Outcome results
None listed