Health Condition 1: Z768- Persons encountering health services in other specified circumstances
Conditions
Interventions
Intervention1: 0.2 mg/kg Dexamethasone diluted in Normal saline(NS) to make a total volume of 10 ml, IV , post induction: Dexamethasone is an anti-inflammatory drug which can reduce neuroinflammation
Sponsors
Dr Vimi Rewari
Eligibility
Inclusion criteria
Inclusion criteria: 1.Adults >60 years age 2.Undergoing elective abdominal surgery of >60 minutes duration under GA( gastrointestinal surgery, gynecological surgery, urological surgery, hepatobiliary surgery) 3.Competent to provide informed consent
Exclusion criteria
Exclusion criteria: 1.Patients who refuse to give consent 2.Patients with preexisting cognitive impairment(Mini mental state examination score 3.Preoperative onset of delirium 4.Patients with uncontrolled diabetes mellitus 5.Visual or hearing disability 6.Drug or alcohol abuse 7.Patients who received any steroid in the last week prior to surgery 8.Patients likely to need intensive care
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| incidence of PSSD in the first three postoperative days using the CAM scoreTimepoint: post-op day 0,1,2 and 3 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. using Numeric Rating Scale (NRS) (0-10), pain at rest and on coughing averaged (arithmetic mean) across postop days 1, 2 and 3. 2. Postoperative cumulative opioid use measured as oral morphine equivalent. 3. Incidence of Postoperative Delirium (PD) in first three postoperative days. 4. Incidence of PSSD which progressed to PD. 5. Identification of risk factors for development of PSSD and PD. 6. Correlation of pain and opioid use with PSSD and PD. 7. Length of hospital stay. 8. 30 day mortality rateTimepoint: post-op day 0,1,2 and 3 | — |
Countries
India
Contacts
Public ContactDr Gaurav agarwal
All India Institute of Medical Sciences
Outcome results
None listed