THE STUDY IS ABOUT TO PREVENTION OF POSTOPERATIVE SORETHROAT IN PATIENTS UNDERGOING GENERAL ANAESTHESIA WITH ENDOTRACHEAL INTUBATION

COMPARISON OF KETAMINE NEBULIZATION AND KETAMINE GARGLE FOR PREVENTION OF POSTOPERATIVE SORETHROAT IN PATIENTS UNDERGOING GENERAL ANAESTHESIA WITH ENDOTRACHEAL INTUBATION-A PROSPECTIVE RANDOMIZED OBSERVER BLINDED STUDY

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/07/043821

Enrollment

100

Registered

2022-07-07

Start date

Unknown

Completion date

Unknown

Last updated

2022-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: ketamine 50mg: patients will recieve nebulization with ketamine 50mg (1ml in 4 ml of normal saline) for 15 minutes. Control Intervention1: ketamine 50 mg: patient will receive ketamine

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA 1&2. 2.Age 20 to 65 years of both sex. 3.Patients undergoing elective surgery under general Anaesthesia with endotracheal intubation lasting upto 3 hours in supine position.

Exclusion criteria

Exclusion criteria: 1. Patient not willing to participate in the study 2. History of prior sore throat and common cold 3. Patient using steroids or Non steroidal anti-inflammatory drugs 4. Patients with chronic obstructive pulmonary disease, asthma and hypertension 5. Anticipated difficult airway 6. Patient requiring more than 2 intubation attempts 7. Traumatic laryngoscopy and intubation 8. Patient having drug allergies to the study drug 9. Surgeries requiring prone position 10. Surgeries lasting more than 3 hours 11. Patients with any contraindication for general anaesthesia 12. Surgery of involving oral cavity, nasopharynx, larynx and neck regions 13. Pregnant women

Design outcomes

Primary

Measure	Time frame
Incidence of Postoperative sorethroat in 2nd postoperative hourTimepoint: Incidence of Postoperative sorethroat in 2nd postoperative hour	—

Secondary

Measure	Time frame
1. Incidence of postoperative sore throat at various time intervals in first postoperative day 2. Severity of postoperative sore throat at various time intervals in the first operative day 3. Patient Acceptability score 4. Duration of laryngoscopy 5. Number of attempts of laryngoscopy 6. Time taken for successful endotracheal intubation 7. Duration of surgery 8. Duration of Anaesthesia 9. Hemodynamics 10. Patient satisfaction scoreTimepoint: 24 hours	—

Measure

Time frame

1. Incidence of postoperative sore throat at various time intervals in first postoperative day 2. Severity of postoperative sore throat at various time intervals in the first operative day 3. Patient Acceptability score 4. Duration of laryngoscopy 5. Number of attempts of laryngoscopy 6. Time taken for successful endotracheal intubation 7. Duration of surgery 8. Duration of Anaesthesia 9. Hemodynamics 10. Patient satisfaction scoreTimepoint: 24 hours

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Countries

India

Contacts

Public ContactVishnupriya

Sri Venkateshwaraa medical college hospital and research center

dr.hari24@yahoo.in7550087722

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026