Health Condition 1: J80- Acute respiratory distress syndrome
Conditions
Interventions
Intervention1: Assessment of intra-operative hemodynamic stability
and post-operative safety and efficacy
: 2-8hrs
Control Intervention1: NA: NA
Sponsors
Department of Anaesthesiology
Department of Anaesthesiology
Eligibility
Inclusion criteria
Inclusion criteria: both sexes; aged 18 to 70 years old; ASA I and II normal renal function with creatinine clearance >30 mL/min.
Exclusion criteria
Exclusion criteria: (I) previous administration of antidepressants, anticonvulsants, or opioids before surgery; (II) serious medical conditions (uncontrolled heart, lung, liver or kidney disease or diabetes); (III) a history of angioedema; (IV) pregnant or nursing; (V) problematic in receiving epidural anaesthesia (spinal deformity, or previous anticoagulation therapy).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be the to investigate the efficacy of pre-emptive analgesia comprised of pre-gabalin versus naproxen in thoracotomy while secondary outcome will be to find out the effects of the COMT gene on modulating pain and its association in thoracotomy along with Assessment of intra-operative hemodynamic stability and post-operative safety and efficacy Timepoint: 48 hrs | — |
Secondary
| Measure | Time frame |
|---|---|
| Patients will be asked to rate their pain (NRS) for the previous 24 hours and their sleep interference rate (SIR) during the previous night, and circled numbers which best described on an 11-point scale, where 0 indicated no pain or sleep interference and 10 will be the worst possible pain or the greatest sleep interference. The NRS and SIR will be assessed on the morning of the 1st, 3rd and 5th day after surgery. Each patient will be visited by a trained questioner who will be blinded to the treatment groups and instructed to fill out the evaluation form.Timepoint: 4HRS | — |
Countries
India
Contacts
Public ContactProf Rajni Gupta
King Georges Medical University Lucknow
Outcome results
None listed