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Effect of ventilation during complete anaesthesia on release of chemicals of lung infection /injury in patients survived from COVID-19

Effect of general anaesthesia with mechanical ventilation on biomarkers of lung inflammation/injury in COVID-19 survivors – A cohort study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/07/043797
Enrollment
40
Registered
2022-07-07
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B972- Coronavirus as the cause of diseases classified elsewhere Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Nil: Nil Control Intervention1: Nil: Nil

Sponsors

Department of Anaesthesiology Pain Medicine and Critical Care AIIMS New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients more or equal to 18 years classified as American Society of Anaesthesiologists (ASA) physical status I/II/ III scheduled for elective or emergency extra thoracic surgery under general anaesthesia 2.Minimum 4 week interval between COVID-19 infection and the scheduled surgery 3.Pulmonary involvement during COVID -19 infection as evident by dyspnea or hypoxemia, chest Xray/CECT findings or oxygen requirement

Exclusion criteria

Exclusion criteria: 1.Post COVID-19 without pulmonary symptoms/radiological involvement/oxygen requirement/undiagnosed COVID. 2.Patients with history or clinical signs of lung disease before COVID-19 infection 3.Patients on ongoing immunosuppression by drugs for underlying condition 4.Elevated leukocyte count or clinical signs of a systemic infection 5.Intra-thoracic surgery 6.ASA class IV

Design outcomes

Primary

MeasureTime frame
To monitor proinflammatory cytokine responses as an estimate of lung inflammation/injury during mechanical ventilation in COVID-19 survivors who had pulmonary involvementTimepoint: baseline, at the end of surgery, 1 hour after the surgery—

Secondary

MeasureTime frame
.To determine incidence of post-operative pulmonary complications (POPC) in patients of general anesthesia with mechanical ventilation .To determine whether serum and bronchoalveolar lavage fluid (BALF) biomarkers are capable of identifying patients at risk of POPC .To determine the correlation between CT score of pulmonary involvement with the serum and BALF biomarkers of lung injury .To assess difference in length of hospital stay of the patients in both groups Timepoint: 7 days and 6 months—

Countries

India

Contacts

Public ContactShreya Shah

AIIMS, New Delhi

shreyabs@hotmail.com09892652781

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026