Health Condition 1: C18- Malignant neoplasm of colon
Conditions
Interventions
Intervention1: Group_0.5: Group_0.5 will receive 50% oxygen during the operation
Intervention2: Group_0.8: Group_0.8 will receive 80% oxygen during the operation
Control Intervention1: Group_0.3: Grou
Sponsors
Department of Health Research
Department of Health Research
Eligibility
Inclusion criteria
Inclusion criteria: ASA I, II patients of either sex between the ages of 18-70 years, having a body mass index between 18-30 kg/m2 and posted for surgery for colonic malignancies will be included in this study.
Exclusion criteria
Exclusion criteria: Patients receiving preoperative chemotherapy, refusal to participate in the study, perioperative blood transfusions, chronic opioid use, renal failure, liver failure, congestive heart failure and co-morbid hematological diseases will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary end point of the study will be effect of different FiO2 on NK cell count (CD56, CD6)Timepoint: Perioperative period | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary end points will be effect of different FiO2 on a. The total T lymphocyte count and counts for the T lymphocyte subpopulations, CD3, CD4, CD8, Th1 and Th2cells. b. Postoperative complications in patients undergoing surgery for colonic malignancies. Timepoint: Perioperative period | — |
Countries
India
Contacts
Public ContactIndira Gurajala
Nizams Institute of Medical Sciences
Outcome results
None listed