Health Condition 1: O- Medical and Surgical Health Condition 2: H178- Other corneal scars and opacities
Conditions
Interventions
Intervention1: Umbilical Cord Patch: Dried Umbilical cord patch will be trimmed according to the size of the corneal defect, and placed over the corneal defect as a graft and will be sutured with 8 to
Sponsors
Regional Institute of Ophthalmology Kolkata
Eligibility
Inclusion criteria
Inclusion criteria: 1. Subject with a known case of corneal perforation and descemetocele due to both infectious and non - infectious cause 2. Subjects with corneal perforation due to trauma 3. Subjects with corneal perforation size between 3.5 to 5.5 mm in diameter 4. Patients with no previous history of keratoplasty 5. In case of bilateral cases, the severely affected eye is included 6. Patients who are willing to sign the informed consent
Exclusion criteria
Exclusion criteria: 1. Corneal perforation 2. Any active corneal infection 3. Corneal scar not easily distinguishable from a current ulcer. 4. Previous penetrating keratoplasty in the affected eye. 5. 6. Pregnancy (by history or urine test) or breast-feeding. 7. Acuity worse than 6/60 (20/200) in the other eye. 8. Known allergy to medications (antibiotics or preservatives). 9. No light perception in the affected eye 10. Patients who are not willing to sign the consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Graft host integration and thickness of corneaTimepoint: 1 month, 3 month, 6 month | — |
Secondary
| Measure | Time frame |
|---|---|
| AC depthTimepoint: 1month, 3month, 6 month;Improvement of visual acuityTimepoint: 1month, 3 months, 6 months;Inflammatory reactionsTimepoint: 1 month, 3 month, 6 month;Measurement of IOPTimepoint: 1 month, 3month, 6 month;Re epithelialisationTimepoint: 1 month | — |
Countries
India
Contacts
Public ContactJayanta Dutta
Deben Mahato Government Medical College & Hospital, Purulia
Outcome results
None listed