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comparison of thoracic epidural versus conventional opioids for measuring ScvO2 in patients undergoing coronary artery bypass grafting

Comparison of Mixed Venous saturation in Patients Undergoing Coronary Artery Bypass Graft Surgery with High Thoracic Epidural versus Conventional Opioids Anaesthesia: A Randomized Control Study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/07/043717
Enrollment
30
Registered
2022-07-05
Start date
Unknown
Completion date
Unknown
Last updated
2022-08-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I257- Atherosclerosis of coronary arterybypass graft(s) and coronary artery of transplanted heart with angina pectoris

Interventions

Intervention1: high thoracic epidural anesthesia: To find out the effectiveness of High Thoracic Epidural Anaesthesia (HTEA) in obtunding the surgical stress response in patients undergoing coronary a

Sponsors

Dr DY Patil medical college and research center
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients undergoing coronary artery bypass grafting â?? ejection fraction > 30%. 2. American Society of Anesthesiology (ASA) grade II, III 3. INR

Exclusion criteria

Exclusion criteria: 1) Unwilling patients 2) Patients with deranged left ventricular function 3) Patients with any neurological and psychiatric disorders. 4) Patients with any contra indications for neuraxial blockade. 5) Patients posted for emergency procedures. 6) History of allergy to any of the drugs being used under study.

Design outcomes

Primary

MeasureTime frame
To find out the effectiveness of High Thoracic Epidural Anaesthesia (HTEA) in obtunding the surgical stress response in patients undergoing coronary artery bypass grafting (CABG) and thereby improving tissue perfusion as measured by mixed venous oxygen saturation.Timepoint: To find out the effectiveness of High Thoracic Epidural Anaesthesia (HTEA) in obtunding the surgical stress response in patients undergoing coronary artery bypass grafting (CABG) and thereby improving tissue perfusion as measured by mixed venous oxygen saturation which we will measure as- baseline, half hour after epidural,on pump, post pump, postop 24 hours—

Secondary

MeasureTime frame
The following points will be considered during the study â?? â?¢ Changes in tissue perfusion by mixed venous saturation. â?¢ Lactate levels. â?¢ Haemodynamic changes in Heart Rate (HR), Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and Mean Arterial Pressure (MAP). â?¢ Arterial blood gas (ABG) analysis. â?¢ Pulmonary arterial wedge pressure. â?¢ Haematocrit. â?¢ Central venous pressure â?¢ Amount of blood transfused and intravenous fluids. Timepoint: baseline, half hour after epidural, on pump, post bypass, post operatively—

Countries

India

Contacts

Public Contactabha juneja

Dr. DY patil medical college and hospital and research center, pimpri, pune

vipulsharmacta@hotmail.com7251888789

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026