Health Condition 1: M170- Bilateral primary osteoarthritis of knee
Conditions
Interventions
Intervention1: Curcumin-Piperine, Probiotics: Curcumin-Piperine (Compounds from turmeric and pepper (1500 mg per day of curcumin and 15 mg per day piperine) and Probiotics (Lactobacillus acidophilus L
Sponsors
University Grants Commission UGC NET JRFSRF Grant
Sami Labs Limited
Eligibility
Inclusion criteria
Inclusion criteria: Subjects with primary unilateral or bilateral knee osteoarthritis with radiographic evidence (Kellgren-Lawrence Grade I or II).
Exclusion criteria
Exclusion criteria: Female patients who are pregnant, lactating, planning to become pregnant, patients who are already taking anti-inflammatory supplements, patients suffering from chronic illnesses that could interfere with the study outcomes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain reduction and functional improvement will be recorded as the primary outcome measures evaluated by the mean change from baseline to end of trial in the VAS (Visual Analogue Scale) pain score and total WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) Score. Timepoint: Baseline, 1 month, 2 month, End of Trial | — |
Secondary
| Measure | Time frame |
|---|---|
| WOMAC subscale score (pain, stiffness and physical function) , Improvement in biochemical parameters (for inflammation), Improvement in clinical parameters, Improvement in Physical function (as measured by 6MWT, TUG, chair stand test and stair climb test). Timepoint: Baseline, End of trial | — |
Countries
India
Contacts
Public ContactAyesha Ashraf Kherani
College of Home Science, Nirmala Niketan
Outcome results
None listed