Health Condition 1: C10- Malignant neoplasm of oropharynx Health Condition 2: O- Medical and Surgical
Conditions
Interventions
Intervention1: Ketamine and dexmeditomidine infusions.: One group of patients will receive ketamine 0.5-1mg/kg/h and dexmeditomidine 0.3-0.7mcg/kg/h infusions
Control Intervention1: Intravenous morphi
Sponsors
Amrita Institute of Medical Sciences Kochi
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients undergoing free-flap surgeries for oral cancer reconstruction 2. All ASA-PS grades
Exclusion criteria
Exclusion criteria: 1. Patients with known hypersensitivity to alpha-adrenoreceptor agonists or ketamine, 2. Patients with known psychiatric illnesses, 3. Patients with history of emergence delirium after ketamine administration, 4. Unplanned re-exploration surgeries with opiates are excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the occurence of post-operative delirium upto 72 hours between opiate and opiate-free anaesthesia groups in oral cancer patients undergoing major resection and reconstruction surgeriesTimepoint: upto 72 hours post-operatively | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To compare the intraoperative haemodynamics between the two groupsTimepoint: Intraoperatively;2. To analyse the effect of ASA grading on occurence of post-operative deliriumTimepoint: First five consecutive post-operative days;3. To evaluate the occurence of post-operative delirium in the subgroup of tracheostomised patientsTimepoint: First five consecutive post-operative days;4. To study the relationship between age and occurence of post-operative deliriumTimepoint: First five consecutive post-operative days;5. To identify factors predisposing to post-operative deliriumTimepoint: Perioperative | — |
Countries
India
Contacts
Public ContactDr Rachita Ajit Naik
Amrita Institute of Medical Sciences, Kochi
Outcome results
None listed