Health Condition 1: I607- Nontraumatic subarachnoid hemorrhage from unspecified intracranial artery
Conditions
Interventions
Intervention1: Remote Ischemic Preconditioning: Patients will undergo Remote Ischemic Pre-conditioning procedure during which arm cuff will be inflated to a pressure of 50 mmHg over systolic blood pr
Sponsors
Apoorva Singh
Eligibility
Inclusion criteria
Inclusion criteria: Ruptured anterior cerebral circulation aneurysm with subarachnoid haemorrhage World Federation of Neurological Surgeons Grade 1 or 2 Posted for Clipping or Coiling of ruptured aneurysm Presentation within 3 days of ictus Consent for participation in the study
Exclusion criteria
Exclusion criteria: Upper limb pathology, such as cellulitis, ulcers, or peripheral vascular disease Posterior circulation aneurysm World Federation of Neurological Surgeons Grade =3 Presentation to hospital beyond 3 days of ictus Refusal of consent • Unruptured aneurysm
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of clinical vasospasm requiring endovascular intervention and managementTimepoint: 0-7 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of vasospasm assessed by Transcranial DopplerTimepoint: 0-7 days;Incidence of vasospasm based on clinical diagnosisTimepoint: 0-7 days;Level of biomarker: serum concentration of eNOS levelsTimepoint: Day 0 and day 7;Neurological status by Glasgow coma scale (GCS) during the study periodTimepoint: 0-7 days;Neurological status by Glasgow Outcome Scale- Extended (GOSE)Timepoint: At 1 and 3 months after discharge;Neurological status by modified Rankin score (mRS)Timepoint: Discharge from hospital | — |
Countries
India
Contacts
Public ContactApoorva Singh
Post Graduate Institute of Medical Education and Research
Outcome results
None listed