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A study to evaluate the efficacy of lignocaine (local anaesthetic drug)and ketamine for preventing pain on injection of rocuronium and propofol.

A Double blind study to evaluate efficacy of pre-treatment with i.v. lignocaine and ketamine over lignocaine alone for preventing the pain associated with rocuronium and propofol administration.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/06/043409
Enrollment
80
Registered
2022-06-22
Start date
Unknown
Completion date
Unknown
Last updated
2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R69- Illness, unspecified

Interventions

Intervention1: Inj. Lignocaine, Inj. Ketamine: Inj. Lignocaine 2% 1cc iv, Inj. Ketamine 25mg iv Control Intervention1: Inj. Lignocaine, Normal Saline: Inj. Lignocaine 2% 1cc, Normal Saline 0.5 cc

Sponsors

DR SWETA SALGAONKAR
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. PATIENT POSTED FOR ELECTIVE SURGERY UNDER GENERAL ANAESTHESIA WITH ENDOTRACHEAL INTUBATION AND POSITIVE PRESSURE VENTILATION. 2. ASA-I AND ASA-II PATIENT

Exclusion criteria

Exclusion criteria: 1. ASA III,IV Patients 2. Patients with known allergy to propofol, rocuronium, lignocaine 3. Patients with neuromuscular disorder or cognitive disorder, high intracranial pressure; uncontrolled hypertension; heart failure; ischaemic heart disease, diabetes mellitus; use of any analgesic drug within the last 24 h; and pregnancy. 4 patients with poor venous access, difficult airway

Design outcomes

Primary

MeasureTime frame
Pain on injection of propofol and rocuroniumTimepoint: 20 sec after injection of propofol, 10 sec after injection of rocuronium—

Secondary

MeasureTime frame
Pulse rate, blood pressure, respiratory rate, spo2, etco2Timepoint: 2min, 5min, 10min—

Countries

India

Contacts

Public ContactDr Yuganti Wange

Seth GS Medical College and KEM Hospital, Parel, Mumbai

yugantiwange@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026