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Comparison of two topical vitamin D analogues in form of ointments in combination with phototherapy in treatment of psoriasis

Comparative evaluation of topical calcipotriol plus Narrow Band ultraviolet B phototherapy versus topical calcitriol plus Narrow Band ultraviolet B phototherapy in treatment of psoriasis - Calcipotriol vs calcitriol with NBUVB in psoriasis treatment

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/06/043333
Enrollment
30
Registered
2022-06-17
Start date
Unknown
Completion date
Unknown
Last updated
2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L400- Psoriasis vulgaris

Interventions

Intervention1: topical calcipotriol plus NBUVB: topical calcipotriol to be applied on right side along with NBUVB thrice per week Control Intervention1: Topical calcitriol plus NBUVB: topical calcitri

Sponsors

Kamal Aggarwal
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with stable plaque psoriasis not exceeding 50% of body surface area involvement of age more than 18 years, according to the rule of nine, was included in this study.

Exclusion criteria

Exclusion criteria: • Patients of age 18 years and below. • Patients who have used systemic antipsoriatic treatment or phototherapy within 2 months prior to the study. • Patients having intolerance or previous failure to phototherapy. • Patients using phototoxic drugs or drugs influencing psoriasis (lithium, beta blockers etc). • Patients with hypersensitivity to calcipotriol or calcitriol. • Patients with known hypercalcemia or hypersensitivity to calcipotriol. • Patients with a history suggestive of photosensitivity or polymorphic light eruptions. • Patients with previous or current carcinoma of the skin or actinic keratosis. • Pregnant patients or lactating mothers.

Design outcomes

Primary

MeasureTime frame
To compare efficacy between topical calcipotriol and topical calcitriolTimepoint: to compare the difference of calcipotriol and calcitriol over 12 week period

Secondary

MeasureTime frame
To compare the safety of the two combinations by assessing the adverse effects.Timepoint: 1 year

Countries

India

Contacts

Public ContactDr Kamal Aggarwal

PT BD Sharma PGIMS Rohtak

drkamalaggarwal@live.in7988658303

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026