Health Condition 1: J80- Acute respiratory distress syndrome
Conditions
Interventions
Intervention1: Prone positioning: Children in the intervention group will be ventilated in the prone position. Proning will be initiated within 24 hours of initiation of invasive ventilation (within s
Sponsors
NIL
Eligibility
Inclusion criteria
Inclusion criteria: 1. Children aged 1 month to 12 years admitted to PICU, 2. Requiring invasive mechanical ventilation, and 3. Fulfilling the PALICC criteria for the diagnosis of mild to moderate PARDS.
Exclusion criteria
Exclusion criteria: 1. Severe hemodynamic instability 2. Burns, trauma 3. Increased intracranial pressure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ventilator free daysTimepoint: At 28 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of mechanical ventilationTimepoint: Till 28 days after randomisation or till discharge, death or transfer out from PICU, whichever is earlier;Oxygenation index at 24 and 48 hoursTimepoint: 24 and 48 hours after initiation of study;Proportion with progression to severe ARDSTimepoint: Till 28 days after randomisation or till discharge, death or transfer out from PICU, whichever is earlier;Trend in the daily Sequential Organ Failure Assessment (SOFA) scoresTimepoint: Till 28 days after randomisation or till discharge, death or transfer out from PICU, whichever is earlier;28-day mortalityTimepoint: 28 days after study initiation;Incidence of adverse events related to prone positioningTimepoint: Till 28 days after randomisation or till discharge, death or transfer out from PICU, whichever is earlier | — |
Countries
India
Contacts
Public ContactDr Karthi N
PGIMER
Outcome results
None listed