Roll of Aparajita (Clitoria ternatea Linn) in the management of Depression

Evaluation of efficacy of Aparajita ( Clitoria Ternatea Linn) in the management of Depression in farmers of vidharbha region chronically exposed to organophosphorous compounds.

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/06/043261

Enrollment

Registered

2022-06-14

Start date

Unknown

Completion date

Unknown

Last updated

2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: T440- Poisoning by, adverse effect of and underdosing of anticholinesterase agents Health Condition 2: R299- Unspecified symptoms and signs involving the nervous and musculoskeletal systems

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: 1) Farmers willing to give written informedconsent. 2) Farmers having age between 18 to 50 yrs. irrespective religion, social and economic status and having chronic exposure to organophosphorus compound for more than 12months. 3) Mild to moderate depression diagnosed by scale will be selected for Serum cholinesteraseinvestigation. 4)) Normal pseudo cholinesterase values ranges between 8 to 18 Units per milliliter. Farmers having Serum cholinesterase values below the 8 units per milliliter will be selected.

Exclusion criteria

Exclusion criteria: 1) Known history of Depression due to other diseases or due toaddiction. 2) Known history of any major illness like hypertension, DM, HIV, Serious cardiovascular disease etc. 3) Exposure to pesticides less 12month 4) Diagnosed with any other mentaldisorder 5) Severe depression diagnosed byScale 6) Farmers with mild to moderate depression but with normal Cholinesterase level.(8 to 18 Units per milliliter)

Design outcomes

Primary

Measure	Time frame
increase in level of serum cholinesterase and decrease in depression Hamilton scoreTimepoint: 24 weeks	—

Secondary

Measure	Time frame
1) To assess the grade of Depression in farmers with the help of Hamilton depression scale. 2) To measure the cholinesterase activity in farmers withDepression. 3) To correlate grade of Depression with cholinesteraselevel. 4) To assess the efficacy of Aparajita root (Clitoria ternatea Linn) on the grade of Depression and cholinesteraselevel. Timepoint: 24 weeks	—

Countries

India

Contacts

Public ContactLaxmikant Paymalle

Mahatma Gandhi Ayurved college Hospital and Research Institute Wardha

dr.nilima_wadnerwar@rediffmail.com8275399319

Outcome results