Comparison of intravenous clonidine vs tranexamic acid for intraoperative blood loss and quality of surgical field during orthognathic surgery

Comparing the effectiveness of intravenous clonidine and tranexamic acid on intraoperative blood loss and quality of surgical field during orthognathic surgery-a randomised clinical trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/06/043194

Enrollment

Registered

2022-06-13

Start date

Unknown

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Q189- Congenital malformation of face and neck, unspecified Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Intravenous Clonidine: Inj clonidine 3microgram/ kg To be administered half an hour before the start of the surgical procedure Total duration of the intervention- time from the beginn

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients of age 18-40years of age 2)Patients in American Society of Anaesthesiology Classification I and II 3) Patient who were candidates for orthognathic surgery

Exclusion criteria

Exclusion criteria: 1) History of systemic disease, coagulopathy, bleeding disorder, vascular anomaly, recent anticoagulant therapy. 2)Patients with bone disease (eg. Fibrous dysplasia) 3) Cleft lip and palate 4) Patients to receive simultaneous temporo- mandibular joint surgery or bone graft harvest

Design outcomes

Primary

Measure	Time frame
Intraoperative blood loss- At the end of the surgical procedure Quality of surgical field-During the surgery Timepoint: Primary outcome: Intraoperative blood loss- at the end of the surgical procedure (Day of surgery) Quality of surgical field- During the surgery (Day of surgery)	—

Secondary

Measure	Time frame
Drop in hemoglobin levels Mean arterial pressure (MAP) Operating timeTimepoint: Drop in hemoglobin levels- After 24 hours Mean arterial pressure- intraoperatively on the day of surgery Operating time- By the end of the surgery (on day of surgery)	—

Countries

India

Contacts

Public ContactSwetha Bhat

Saveetha Dental College and Hospital

151904006.sdc@saveetha.com7204078811

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026