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A Study to understand the importance of computer software to identify the eye diseases

Prospective Study for Ocular and Systemic Pathologies

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/06/043171
Enrollment
14400
Registered
2022-06-10
Start date
Unknown
Completion date
Unknown
Last updated
2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H350- Background retinopathy and retinalvascular changes

Interventions

None listed

Sponsors

Google LLC
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Able to complete adequate or reliable image acquisitions in one or both eyes. 2) Diagnosis of Primary Open Angle Glaucoma (POAG) or Primary Angle Closure Glaucoma (PACG) based on IOP, Fundus photographs or OCT scans changes showing Notch, Rim loss, Disc hemorrhage, Nerve Fiber Layer defect, Peripapillary atrophy and Visual Field defects. 3) Diagnosis of retinal pathologies (DR, AMD, vascular occlusions, macular hole, epiretinal membrane, retinal detachment, hypertensive retinopathy, disc edema, posterior uveitis) based on structural changes seen in Fundus or Ultra widefield fundus photographs or OCT or OCTA.

Exclusion criteria

Exclusion criteria: 1) History of trauma or injury to the eye/ symptomatic inflamed eyes 2) Significant media opacity that precludes acquisition of images. 3) Any physical disability which will preclude the patients from performing necessary study investigations 4) Pregnant and Nursing women

Design outcomes

Primary

MeasureTime frame
Successful enrollment of participants and prospective collection ocular images, clinical exam findings and blood tests providing a robust ground truth to train and validate a deep learning algorithm that can identify novel signals - for example systemic disease - and detect or predict progression of ocular pathologies identified in the studyTimepoint: 24 months

Secondary

MeasureTime frame
To identify novel signals in retinal imaging that may predict early signs of glaucoma, retinal pathology as well as its systemic associationTimepoint: 24 months

Countries

India

Contacts

Public ContactDr R Kim

Aravind Eye Hospital and Postgraduate Institute of Ophthalmology

kim@aravind.org914524356100

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026