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Two different strategies to determine optimum PEEP to prevent postoperative pulmonary complications

Comparison on the occurrence of Postoperative pulmonary atelectasis with driving pressure-guided PEEP and conventional PEEP applied during general anaesthesia in patients undergoing Laparoscopic or Robotic Pelvic surgery: A double blind randomised controlled trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/06/043159
Enrollment
128
Registered
2022-06-10
Start date
Unknown
Completion date
Unknown
Last updated
2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Driving pressure guided positive end expiratory pressure.: Driving pressure guided Positive End Expiratory Pressure(PEEP) applied during general anesthesia in preventing Atelectasis in

Sponsors

AIIMS Jodhpur
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged between 18 years to 65 years of either sex, American Society of Anesthesiologists (ASA) physical status I/II grade Body mass index (BMI) between 18-30 kg/m2 Patients undergoing robotic or laparoscopic pelvic surgeries with anticipated duration of >3 hours.

Exclusion criteria

Exclusion criteria: 1.Patients not willing to participate in the study 2.Patients with significant cardiac, respiratory, renal, and hepatic disease 3.Patients requiring elective postoperative mechanical ventilation

Design outcomes

Primary

MeasureTime frame
To compare the atelectasis by using lung ultrasound score (LUS) before induction, after induction and at completion of surgery before extubation at 12 lung areas between groups.Timepoint: Primary outcome will be assessed at the end of surgery.—

Secondary

MeasureTime frame
1.To compare the intra operative and postoperative oxygenation (PaO2/FiO2 ratio, A-a DO2 and SpO2) between groups. 2.To compare the intra operative respiratory mechanics â?? Lung compliance (CL), Lung Elastance (EL), Plateau Pressure (PPLAT) and Peak Pressure (PPEAK) between groups. 3.To compare the intraoperative hemodynamic parameters - Mean Blood Pressure (MAP), Heart Rate (HR) and Pulse Pressure (PP) between groups. 4.To compare the adverse respiratory events post-operatively within 5 days â?? requirement of oxygen supplementation, any episodes of desaturation, respiratory failure between groups. Timepoint: final secondary outcome will be assessed in first 5 days of post-operative period.—

Countries

India

Contacts

Public ContactDR PRASANNA PADMANABHA

ALL INDIA INSTITUTE OF MEDICAL SCIENCES, JODHPUR

geethamanoj007@yahoo.co.in9414084584

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026