Health Condition 1: 4- Measurement and Monitoring Health Condition 2: I258- Other forms of chronic ischemic heart disease Health Condition 3: I058- Other rheumatic mitral valve diseases Health Condition 4: I078- Other rheumatic tricuspid valve diseases Health Condition 5: I081- Rheumatic disorders of both mitraland tricuspid valves Health Condition 6: I051- Rheumatic mitral insufficiency Health Condition 7: I050- Rheumatic mitral stenosis Health Condition 8: I052- Rheumatic mitral stenosis with
Conditions
Interventions
Intervention1: Injection Dexmedetomidine: Nebulisation in pre-operative period @ 1mcg/kg body weight diluted to 3ml, stat, for 10 mins duration
Control Intervention1: Normal saline: Nebulisation with
Sponsors
None
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion Criteria 1. Age 18-55 years 2. Both genders 3. Elective cardiac surgery 4. Mitral valve repair or replacement 5. Mitral stenosis, mitral regurgitation 6. Coronary artery bypass graft with mitral valve replacement
Exclusion criteria
Exclusion criteria: EXCLUSION CRITERIA 1. Anticipated difficult airway. 2. Preoperative heart rate 3. Uncontrolled AF and ventricular rate 4. Second degree heart block and bundle branch blocks 5. Patients with both mitral and aortic valve disease 6. Right atrial mass or thrombus 7. Emergency surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Compare change in pulmonary artery systolic pressure (PASP) and mean pulmonary artery pressures (mPAP) during laryngoscopy and intubation.Timepoint: Within 2 successful intubation attempts | — |
Secondary
| Measure | Time frame |
|---|---|
| Compare change in pulmonary vascular resistance (PVR)during laryngoscopes and intubationTimepoint: every 1 minute of induction of anesthesia till 15 minutes following intubation;Compare dose of inotropes or vasopressors requiredTimepoint: every 1 minute of induction of anesthesia till 15 minutes following intubation;Compare dose of propofol and fentanyl required during intubation response to optimise blood pressureTimepoint: every 1 minute of induction of anesthesia till 15 minutes following intubation;Compare PASP and systolic blood pressure (SBP) ratio (PASP/SBP) during laryngoscopy and intubationTimepoint: every 1 minute of induction of anesthesia till 15 minutes following intubation;Compare PASP, PADP, mPAP, PVR, SBP, DBP, MAP, systemic vascular resistance, cardiac output (CO) and cardiac index (CI)Timepoint: every 1 minute of induction of anesthesia till 15 minutes following intubation | — |
Countries
India
Contacts
Public ContactDr Ajay Kumar
All India Institute Of Medical Sciences , Rishikesh
Outcome results
None listed