Health Condition 1: C509- Malignant neoplasm of breast of unspecified site
Conditions
Interventions
Intervention1: melatonin: 3mg+3mg of melatonin to be given to check th effect on perioperative anxiety
Control Intervention1: alprazolam: 0.25 mg + 0.25 mg of alprozolam to be given to check the effec
Sponsors
Department of Anaesthesia and Intensive Care
Eligibility
Inclusion criteria
Inclusion criteria: Adult females of ASA physical status 1 & II, between the age group of 18-60 years scheduled to undergo breast cancer surgery under general anaesthesia
Exclusion criteria
Exclusion criteria: Patients which are- 1. Above 60 years of age 2. ASA III and IV 3. Have a history of any neuropsychiatric illness 4. Already on antiepileptic ,antipsychotic and anticholenergic drugs • With uncontrolled HTN, diabetes or thyroid disorders. • Unable to read or write • Unable to understand the scoring systems used in the study • With history of any allergy to study drugs • Refusal to give consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Anxiety as measured by State Trait Anxiety Inventory (STAI) , 90 minutes after morning dose of oral Melatonin / Alprazolam.Timepoint: 1.Night before surgery 2.90 minutes after morning dose of the study drug | — |
Secondary
| Measure | Time frame |
|---|---|
| Baseline Anxiety, anxiety levels 6 hours after surgery, Cognitive Functions (DSST), VAS Sleep score , sedation score (MOASS) , Orientation and any adverse effect.Timepoint: 1.Night before surgery 2.90 minutes after morning dose of the study drug 3.6 hours after surgery 4.24 hours after surgery | — |
Countries
India
Contacts
Public Contactpulkit bansal
post graduate institute of medical education and research
Outcome results
None listed