A Randomized clinical study to check the inter-appointment pain in patients with infected teeth using two different combination of drugs

Comparative evaluation of two different intracanal medicament regimes for inter-appointment pain management in infected single rooted teeth with Symptomatic Apical Periodontitis- A Randomized double-blinded Clinical Study.

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/06/043007

Enrollment

Registered

2022-06-03

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K044- Acute apical periodontitis of pulpal origin

Interventions

Intervention1: MODIFIED DOUBLE ANTIBIOTIC PASTE: IT CONSISTS OF METRONIDAZOLE-5oomg,CIPROFLOXACIN-500mg AND VALACYCLOVIR-500mg. Application for once after 1st visit as a intra canal medicament for 6 d

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy patients between age group of 18-60 years with maxillary or mandibular single rooted infected/necrotic teeth with symptomatic apical periodontitis will be included in the study. Symptomatic chronic irreversible pulpitis with symptomatic apical periodontitis with loss of lamina dura will be included. Symptomatic teeth showing presence of peri-apical radiolucency suggestive of periapical abscess will be included. patients with pre-operative moderate to severe pain will be included. A written informed consent will be taken and only those patients ready to sign the consent will be included in the study.

Exclusion criteria

Exclusion criteria: Asymptomatic teeth with periapical radiolucencies be it abscess or granuloma, etc will be excluded. Medically compromised patients will be excluded. Teeth with completely obliterated canals will be excluded. Teeth with open apex, root resorption or complex root canal anatomy will be excluded. Teeth with vertical root canal fractures, cracks, etc will be excluded. Patients with deep periodontal disease or endo-perio lesion with periodontal phase dominant will be excluded. Pregnant and lactating women will be excluded. Patients using other medications such as analgesics or anti-inflammatory drugs during inter appointment will be excluded. Patients allergic to antibiotics and anti-viral drugs will be excluded.

Design outcomes

Primary

Measure	Time frame
Interappointment pain assessmentTimepoint: 6hr,12 hr,24hr,3 days,6days	—

Secondary

Measure	Time frame
efficacy of modified double antibiotic paste in pain managementTimepoint: 6hr,12 hr,24hr,3 days,6days	—

Countries

India

Contacts

Public ContactDr Ajay singh rao

km shah dental college

drajayinendo@gmail.com8385017307

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026