Health Condition 1: F200- Paranoid schizophrenia
Conditions
Interventions
Intervention1: Probiotics: Probiotic blend 10 billion CFU, L- glutamine 250mg.Available in sachet form. Route of administration - oral. Each patient will be given 2 sachet per day for 12 weeks.
Contro
Sponsors
VIBRONICA A Division of Kepler heathcare Pvt Ltd
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients aged 18-45 years. 2.ICD -10 diagnosis of schizophrenia any type or schizoaffective disorder with disease duration of atleast 2 years. 3.Willing to participate in the study 4.Education of 9th std and above 5.Scores on the Positive and Negative Syndrome Scale (PANSS) indicative of at least moderately severe psychosis, total PANSS score >= 50. 6.Cognitive deficit below 15th percentile in any one cognitive domain of NIMHANS battery.
Exclusion criteria
Exclusion criteria: 1.Patients who are uncooperative due to the severity of the illness. 2.Existence of serious medical/neurological disorder, known allergic to Probiotics. 3.Patients with diagnosis of mental retardation. 4.Primary diagnosis of substance abuse or dependence within the last 3 months. participated in any investigational drug trial in the past 30 days; 5.Women who were currently pregnant, planning to get pregnant /breastfeeding. Not consenting to participate in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| fasting serum insulin, insulin resistance, body mass index, fasting blood glucose, lipid profile and body weightTimepoint: baseline and 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| PANSS scores cognitive symptoms (executive function, attention and memory)Timepoint: baseline, 4 ,8 and 12 weeks. | — |
Countries
India
Contacts
Public ContactHema Tharoor
Schizophrenia Research Foundation
Outcome results
None listed