Health Condition 1: K810- Acute cholecystitis Health Condition 2: O- Medical and Surgical
Conditions
Interventions
Intervention1: Dexmedetomidine: Intravenous dexmedetomidine 0.5 �µg/kg dissolved in normal saline upto 10 ml drug solution 10 min before extubation.
Control Intervention1: Esmolol: Esmolol bolus dos
Sponsors
Dr Rashmi Naik Bhuaarya
Eligibility
Inclusion criteria
Inclusion criteria: ASA Physical Status ââ?¬â?? I & II BMI (18.5-24.9) Patient undergoing elective surgery under general anaesthesia and endotracheal intubation
Exclusion criteria
Exclusion criteria: Patientââ?¬•s refusal Patient with known allergy to dexmedetomidine and esmolol Surgery lasting for more than two hour Patient with h/o hypertension, ischaemic heart disease, aortic stenosis, left ventricular failure, atrio-ventricular conduction block sinus bradycardia, asthma, chronic obstructive pulmonary disease Severe hepatic and renal disease Patient receiving antihypertensives, MAO inhibitors Pregnant and lactating woman Cases encountered with difficult intubation Anticipated difficult airway Novel corona virus positive
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Variation in heart rate and blood pressureTimepoint: Variation in heart rate and blood pressure baseline, during extubation and 1 min, 2 min, 3 min, 4 min, 5 min, 6 min post extubation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Variation in 5-point rating scale(Extubation quality score), time to eye opening, Ramsay sedation score, adverse effectsTimepoint: Variation in 5-point rating scale(Extubation quality score) immediately after extubation, Ramsay sedation score 6 minutes post extubation | — |
Countries
India
Contacts
Public ContactDr Rashmi Naik Bhuaarya
PT JNM MEDICAL COLLEGE
Outcome results
None listed