Role of vitamin supplementation on central retinal watery accumulation after branch retinal vein obstruction in the patients with high blood homocysteine level

EFFECT OF VITAMIN SUPPLEMENTATION ON MACULAR OEDEMA DUE TO BRANCHED RETINAL VEIN OCCLUSION IN PATIENTS WITH HYPERHOMOCYSTEINEMIA

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/05/042928

Enrollment

Registered

2022-05-31

Start date

Unknown

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intravitreal injection Ranibizumab (10 mg/ml) (0.5 mg)plus oral vitamin supplementation: Intravitreal injection Ranibizumab (10 mg/ml) (0.5 mg/0.05 ml)per month for 3-months with fixed

Eligibility

Inclusion criteria

Inclusion criteria: 1. Involvement of one or both eyes by BRVO with macular edema with log MAR visual acuity worse than 0.30 (Snellen equivalent 6/12) (if both eyes are involved right eye will be included as a case) 2. High plasma homocysteine levels

Exclusion criteria

Exclusion criteria: 1. Patients with dyslipidaemia 2. Systemic hypertension, Diabetes Mellitus with Diabetic retinopathy 3. Ocular hypertension, glaucoma 4. H/O Smoking 5. Undergoing hormonal therapy 6. Previously diagnosed coagulation disorder other than hyperhomocysteinemia 7. Under any medication related to blood coagulation

Design outcomes

Primary

Measure	Time frame
1. Visual improvement 2. Reduction in centra;l Macular Thickness Timepoint: 3 months	—

Secondary

Measure	Time frame
1.Reduction in the homocysteine level in the bloodTimepoint: 3 months	—

Countries

India

Contacts

Public ContactSoumyadeep Majumdar

Regional Institute of Ophthalmology, MCH campus,Kolkata

soumyanbmc@gmail.com09647683105

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026