Health Condition 1: M00-M99- Diseases of the musculoskeletal system and connective tissue Health Condition 2: M968- Other intraoperative and postprocedural complications and disorders of musculoskeletal system, not elsewhere classified
Conditions
Interventions
Intervention1: Tamsulosin: Tamsulosin 0.4mg OD from the time of admission to two days postoperatively
Control Intervention1: Placebo: Starch capsule OD from the time of admission to two days postopera
Sponsors
AIIMS Bhubaneswar
Eligibility
Inclusion criteria
Inclusion criteria: 1. All patients undergoing hip fracture surgery (ORIF or arthroplasty) 2. >=18 years of age. 3. Patients willing to participate
Exclusion criteria
Exclusion criteria: 1. History of neurogenic bladder or urological problems requiring routine intermittent catheterization 2. Patients unable to take an oral medication 3. Patient who would require an indwelling catheter for other reasons, or patients who needed catheterisation during admission to the emergency for voiding difficulty 4. Patients with systolic blood pressure 5. Pregnant women 6. Associate trauma of spine or pelvis 7. Patients taking medications for lower urinary tract symptoms or who had previously undergone prostatectomy 8. Patients with severe liver or kidney disease 9. Patients taking strong inhibitors of CYP3A4 (ketoconazole, itraconazole, clarithromycin, ritonavir/ritonavir, lopinavir/ritonavir, or conivaptan), use of a 5-alpha reductase inhibitor medication, the use of sildenafil, tadalafil, or vardenafil, history of an allergy or sensitivity to tamsulosin or other alpha-blockers (alfuzosin, doxazosin, prazosin, Terazosin, or phenoxybenzamine), 10. Uncontrolled concomitant illness including, but not limited to, ongoing or active infection 11. Congestive heart failure, unstable angina pectoris, cardiac arrhythmia, 12. Psychiatric illness
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Number of patients developing postoperative urinary retention (POUR)Timepoint: 6 hours of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. No. of patients needing urinary catheter placement (unable to void, bladder scan with 500 mL residual urine or patient discomfort) 2. No. of intermittent catheterization 3. Total days of hospital stay 4. Analgesic use 5. No. of patient developing UTI or surgical site infection 6. No. of patient developing other complications such as VTE, pneumonia, hypotension or cardiac event Timepoint: within hospital admission period | — |
Countries
India
Contacts
Public ContactSujit Kumar Tripathy
AIIMS Bhubaneswar
Outcome results
None listed