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Effect of Calcium supplementation on reversal of metformin (drug used for treatment of T2DM patients) induced Vitamin B12 malabsorption in normal, nondiabetic individuals

Effect of calcium supplementation on reversing the inhibitory effect of Metformin on the Bioavailability of Vitamin B12 in normal, non-diabetic individuals

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/05/042886
Enrollment
8
Registered
2022-05-27
Start date
Unknown
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Metformin hydrochloride and Calcium Carbonate: Metformin hydrochloride 850mg (Glycomet 850 tablets) + Calcium Carbonate 500mg (Shelcal 500 tablets) administered 3 times in 24 hours Cont

Sponsors

Clinical Research Centre Department of Physiology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Subjects should be aged between 18 to 40 years Subject BMI

Exclusion criteria

Exclusion criteria: Subjects with history of self-reported diabetes mellitus Subjects showing clinical symptoms or signs of Vitamin B12 deficiency or found to have B12 deficiency on screening Subjects with any chronic disease or under any medication Subjects with history of gastric acidity, gastritis or malabsorption Subjects with reported anemia or diagnosed with anemia during screening Subjects with history of renal disorders and with increased blood creatinine

Design outcomes

Primary

MeasureTime frame
Vitamin B12 BioavailabilityTimepoint: 7 hours after administration of Metformin or Metformin and Calcium Doses—

Secondary

MeasureTime frame
Decrease in Vitamin B12 bioavailability upon Metformin AdministrationTimepoint: 7 hours after administration of Metformin doses—

Countries

India

Contacts

Public ContactGunjit Glen Romould

St. Johns Medical College

jananeemuralidharan@gmail.com9742170112

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026