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A Study to compare the effect of three drugs -Dexmedetomidine, Lidocaine and Fentanyl in increasing heart rate and blood pressure in response to Laryngoscopy and Intubation in patients undergoing Cardiac Surgery

A prospective, randomized, double blinded, controlled study for comparison of Dexmedetomidine, Lidocaine and Fentanyl in attenuation of Hemodynamic response to Laryngoscopy and Intubation in patients undergoing Cardiac Surgery at SMS Medical College, Jaipur

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/05/042885
Enrollment
90
Registered
2022-05-27
Start date
Unknown
Completion date
Unknown
Last updated
2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intravenous Dexmedetomidine: 1 microgram/kg of Intravenous Dexmedetomidine for 10 minutes before laryngoscopy Intervention2: Intravenous Fentanyl: 2 microgram/kg of Intravenous Fentanyl

Sponsors

Department of Anaesthesiology
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Informed Consent 2.Patients undergoing Elective Cardiac Surgery 3.Ejection Fraction >35% 4.ASA Grade 2 and 3 5.BMI <30

Exclusion criteria

Exclusion criteria: 1.Intubation Attempt lasting longer than 15s and any intubation related problem 2.Allergic Sensitivity to the research medications 3.Patients with hypotension(SBP 4.Bradycardia(HR 5.Diabetes 6.Asthma 7.Pregnancy 8.Chronic Kidney and liver diseases 9.Long QT 10.Any Addiction

Design outcomes

Primary

MeasureTime frame
Heart Rate, Systolic Blood Pressure, Diastolic Blood Pressure, Mean Arterial PressureTimepoint: Before Intubation and 1,3,5,10 and 15 minutes post intubation—

Secondary

MeasureTime frame
Percentage of cases who experience side effects or complications(if any)Timepoint: 24 hours postoperation—

Countries

India

Contacts

Public ContactDr Karthik K

S.M.S Medical College, Jaipur

dr.induverma@gmail.com9413622967

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026