Effectiveness of oral proteolytic enzymes in post operative sequelae following third molar surgery- A double blinded randomised clinical trial.

Effectiveness of oral proteolytic enzymes in post operative sequels following third molar surgery- A double blinded randomised clinical trial.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/05/042881

Enrollment

Registered

2022-05-27

Start date

Unknown

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R00-R99- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Interventions

Intervention1: Oral Bromelain: 500 mg BD x 5 days ( 30 mins before food) Bromelain is a group of enzymes found in pineapple juice and in the pineapple stem. Bromelain seems to cause the body to produc

Eligibility

Inclusion criteria

Inclusion criteria: patientâ??s age above 18 years and above, mesioangular and horizontal third molars position A and B impactions, symptomatic patients.

Exclusion criteria

Exclusion criteria: history of any systemic disease, History of known allergy to above medications, pregnancy

Design outcomes

Primary

Measure	Time frame
1)Swelling- 3 point measurement 2)Trismus- interincisal distance Timepoint: All outcomes to be measured Pre operatively just before surgery ,2nd and 7th day post operative day.	—

Secondary

Measure	Time frame
Pain- VAS scale on a scale of 1 to 10.Timepoint: Outcomes to be measured Pre operatively just before surgery,2nd and 7th post operative day.	—

Countries

India

Contacts

Public ContactVivek D Menon

Saveetha Dental College and Hospital

muthusekhar55@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026