Health Condition 1: F20-F29- Schizophrenia, schizotypal, delusional, and other non-mood psychotic disorders
Conditions
Interventions
Intervention1: True Transcranial Alternating current Stimulation: Alpha-tACS will be administered to patients with schizophrenia at 10-Hz in a resting awake state for the initial 5-days in RCT. All pa
Sponsors
Department of Psychiatry National Institute of Mental Health and Neuro Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1.Meeting DSM-5 criteria for schizophrenia and related disorders 2. At least one adequate antipsychotic trial 3. Patient is currently on a stable dose of antipsychotics for a minimum of 6-weeks 4. Presence of psychotic symptoms with any of the global subscale’s scores of SAPS=3 5. Written informed consent (with the capacity to consent)
Exclusion criteria
Exclusion criteria: 1. Subjects with contraindications for tACS/magnetic resonance imaging 2. Comorbid intellectual and developmental disabilities, epilepsy, substance dependence, and Pregnancy/postpartum period.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Change in resting state connectivity of mPFC 2.Change in positive symptoms (SAPS score)Timepoint: After 5-days of tACS | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Change in clinical scores: [Clinical symptoms (SANS, PSYRATS delusions and hallucinations scores), executive function (BACS), social cognition (SOCRATIS) and emotion cognition (TRENDS)]. 2.Change in the TEP measures 3.Changes in the clinical symptoms and TMS Evoked Potentials (TEP) measuresTimepoint: After 5-days and 10-days of tACS | — |
Countries
India
Contacts
Public ContactG Venkatasubramanian
National Institute of Mental Health and Neurosciences (NIMHANS)
Outcome results
None listed