Effect of Dexmedetomidine on brain blood vessel related blood tests in abnormal brain blood vessel bleed patients undergoing surgery under general anesthesia.

Effect of dexmedetomidine on cerebral vasospasm associated biomarkers in patients undergoing elective craniotomy for intracranial aneurysms: a randomized controlled trial.

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/05/042738

Enrollment

Registered

2022-05-23

Start date

Unknown

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G94- Other disorders of brain in diseases classified elsewhere

Interventions

Intervention1: Dexmedetomidine: @0.2-0.7 mcg/kg/hr intravenous route during maintenance of anesthesia[ after induction of anesthesia till end of surgery] Control Intervention1: Fentanyl: @ 1 mcg/kg/hr

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient who gives Informed Consent 2. Patients with anterior circulation aneurysms 3. WFNS grade 1 aneurysm 4. Age between 18-65 years 5. ASA grade 1 and 2 6. Both gender 7. MMSE 24-30

Exclusion criteria

Exclusion criteria: 1. Patients not giving consent 2. Patients with posterior circulation aneurysm 3. Age 65 years 4. ASA grade 3,4,5 5. Pregnant patients 6. WFNS grade 2,3,4

Design outcomes

Primary

Measure	Time frame
1. Biomarker Serum IL6, CRP and S100-Î² levelsTimepoint: 24 hrs after surgery.	—

Secondary

Measure	Time frame
1. Detection of Mean flow velocity [MFV] in cm/sec in middle cerebral artery [MCA] using transcranial Doppler [TCD]Timepoint: 24 hrs after surgery.;2. Neurological outcome [using Mini Mental State Examination [MMSE]Score]Timepoint: 24 hrs after surgery.;3. Glasgow Outcome Scale Extended [GOSE]Timepoint: at discharge and 28 days	—

Countries

India

Contacts

Public ContactIndu Kapoor

AIIMS, NEW DELHI

dr.indu.me@gmail.com09013439134

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026