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To compare the effect of nalbuphine versus fentanyl on pressor response during intubation under general anaesthesia and also compare their analgesic property.

A prospective randomised clinical study to compare the effect of Nalbuphine vs Fentanyl on attenuation to pressor response during endotracheal intubation and analgesic potential on patient under general anaesthesia

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/05/042731
Enrollment
70
Registered
2022-05-23
Start date
Unknown
Completion date
Unknown
Last updated
2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: inj. Fentanyl: Attenuation to pressor response and duration of analgesia by using inj. fentanyl at dose 2mcg/kg iv slow for 5 minutes before induction is assessed in pateint under gener

Sponsors

Jawaharlal Nehru Medical College and Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Either sex Age group 18-65 years Body weight 40-70 kg ASA grade 1 and 2 Scheduled for surgery under general anaesthesia

Exclusion criteria

Exclusion criteria: Patients not willing to participate in study Uncooperative patients Patients with history of drug allergy Patients with pre-existing asthma, renal or hepatic dysfunction Pregnancy/lactation Morbid obese patient

Design outcomes

Primary

MeasureTime frame
Hemodynamic variability in both groups : heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure.Timepoint: Perioperatively—

Secondary

MeasureTime frame
1.BIS-guided total requirement of analgesic drug in both groups 2. Time required for first rescue analgesic in both groups 3. Side effects and complications of both drugs if any.Timepoint: Perioperatively—

Countries

India

Contacts

Public ContactDr Maina Singh

Jawaharlal Nehru Medical College and Hospital, Ajmer, Rajasthan

mainasingh111@gmail.com9414097045

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 7, 2026