A study to compare the effect of dexmedetomidine versus ketamine in fracture femur patients

Comparison of the effect of intravenous bolus and infusion of dexmedetomidine versus ketamine given intraoperative on postoperative analgesia in fracture femur patients operated under subarachnoid block - A prospective randomized controlled trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/05/042695

Enrollment

Registered

2022-05-20

Start date

Unknown

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Dexmedetomidine: 1 mcg/kg bolus followed by infusion of 0.5mcg/kg/hour till the end of surgery Control Intervention1: Ketamine: 0.3mg/kg bolus followed by infusion of 0.15mg/kg/hour til

Eligibility

Inclusion criteria

Inclusion criteria: 1)Patients of either sex 2)Patients with ASA grade 1 and grade 2 3)Patients aged between 18 to 65 years 4)Patients with femur fractures

Exclusion criteria

Exclusion criteria: 1)Refusal to participate in the study 2)Peripheral neuropathy 3)Patients having coagulation or bleeding abnormalities 4)Local site infection 5)Altered mental status 6)Patients with significant coexisting diseases like ischemic heart disease, impaired renal function and severe liver disease 7)Patients on beta blockers 8)Patients allergic to bupivacaine, dexmedetomidine, ketamine

Design outcomes

Primary

Measure	Time frame
To compare postoperative analgesia and duration of analgesia after fracture femur surgery in dexmedetomidine versus ketamine groupTimepoint: 1 year	—

Secondary

Measure	Time frame
cumulative analgesic requirements, hemodynamic effects, side effectsTimepoint: 1 year	—

Countries

India

Contacts

Public ContactDR RANA ATHER

NIZAMS INSTITUTE OF MEDICAL SCIENCES

sapnanikhar@gmail.com08297710738

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026