None listed
Conditions
Interventions
Intervention1: 2mg Vitamin K: Routinely, vitamin K is given as 1 mg to all newborn at birth. In this study, 2mg vitamin K will be given one group and compared with another group receiving 1 mg
Control
Sponsors
JIPMER Intramural Research Fund
Eligibility
Inclusion criteria
Inclusion criteria: Term neonates with appropriate for gestational age between 37 weeks to 42 weeks born by spontaneous vaginal delivery with normal Apgar scores ( >8/10 at 1 min).
Exclusion criteria
Exclusion criteria: Mother taking antiepileptics, anti-tubercular drugs and warfarin Mother received vitamin K within one week of delivery. Bleeding disorder in the family members (mother or sibling or father) and any first-degree relatives. Suspected case of bleeding disorder in the neonate
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Subclinical vitamin deficiency (as measured by elevated PIVKA II level) will be lower in neonates who received 2mg vitamin K compared to neonates who received 1 mg at end of 1 month.Timepoint: PIVKA levels will be measured at birth from cord blood. PIVKA levels will be next measured in the child at 1 month of age. And PIVKA will be measured during 6 weeks immunisation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Number of bleeding episodesTimepoint: 30 days 72 days | — |
Countries
India
Contacts
Public ContactAmala Srilatha Natarajan
Jawaharlal Nehru Institute of Post graduate Medical Education and Research, Puducherry
Outcome results
None listed