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A clinical study to study comparing the effect of premedication with steroids and NSAID on success of local anaesthesia of lower molars

Effect of oral premedication with steroids in comparison to NSAID on anesthetic success of Inferior alveolar nerve block in mandibular molars with symptomatic irreversible pulpitis â?? A randomized clinical trial - SKIE

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/05/042568
Enrollment
184
Registered
2022-05-17
Start date
Unknown
Completion date
Unknown
Last updated
2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Prednisolone: 1 tablet of 20mg, administered 1 hour prior to the root canal treatment Intervention2: Dexamethasone: 1 tablet of 4mg administered one hour prior to the root canal treatme

Sponsors

Dr Vivek Hegde
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Mandibular molars diagnosed with symptomatic irreversible pulpitis. 2. Absence of periapical changes in radiographs (Periapical Index lesser or equal to 2)).

Exclusion criteria

Exclusion criteria: 1. Teeth with fractures 2. Teeth with necrotic pulps following access opening (no bleeding from canals) 3. Teeth diagnosed as acute or chronic apical abscess. 4. Teeth with immature apices 5. Patients with any systemic diseases 6. Patients having history of allergy to local anesthetic solutions or any of the experimental drugs 7. Patients who could not understand the pain scale 8. Patients on long term medications. 9. Patients who were unable to provide informed consent

Design outcomes

Primary

MeasureTime frame
Effect of preoperative oral 20mg Prednisolone, 4mg dexamethasone, 10mg ketorolac on the anesthetic success of inferior alveolar nerve blocks (IANBs) in mandibular molars with symptomatic irreversible pulpitis. Timepoint: 90 minutes—

Secondary

MeasureTime frame
Adverse effect like paresthesia and pain on injection siteTimepoint: 24 hours;Assess the onset of lip anesthesia Timepoint: 10 minutes—

Countries

India

Contacts

Public ContactDr Srilatha S

M.A.Rangoonwala Dental College and Research Centre

drsri2005@gmail.com9822055434

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026