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To compare the effects of two drugs - propofol TIVA and dexmedetomidine with sevoflurane anaesthesia over the motor evoked potentials readings obtained during detethering surgeries

Comparison of Propofol TIVA versus dexmedetomidine and sevoflurane on the amplitude of cMAP during transcranial MEP monitoring in infants undergoing detethering surgeries

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/05/042452
Enrollment
16
Registered
2022-05-11
Start date
Unknown
Completion date
Unknown
Last updated
2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Q00-Q99- Congenital malformations, deformations and chromosomal abnormalities Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: PROPOFOL TIVA: Patients in this group will be maintained on a propofol infusion based on the Eleveld-H PKPD model targeting an effect site plasma concentration of 3 μg.ml-1.In case rep

Sponsors

DEPARTMENT FUND AMRITA INSTITUTE OF MEDICAL SCIENCES
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Infants posted for myelomeningocele repair

Exclusion criteria

Exclusion criteria: 1. Significant cardiac disease 2. any inborn error of metabolism including mitochondrial disorders

Design outcomes

Primary

MeasureTime frame
To compare propofol anaesthesia versus dexmedetomidine â?? sevoflurane anaesthesia with respect to the amplitude of cMAPs during tcMEP recorded from the upper and lower limbs in infants.Timepoint: At the baseline and at point of surgery when they enter the dura—

Secondary

MeasureTime frame
1.To compare the recovery profile of both anaesthetic protocols 2.Compare groups with respect to intraoperative MEP loss and global suppression of amplitudes. Timepoint: At the baseline, time at when they enter the dura and at time of extubation—

Countries

India

Contacts

Public ContactVarshini R

AMRITA INSTITUTE OF MEDICAL SCIENCES

mathew.doc@gmail.com9447841795

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026