To see the effect of Rumination Focused Cognitive Behaviour Therapy and Cognitive Retraining on cognitive symptoms of depression and its correlates of brain functioning as measured by fMRI.

TRIPLE MODE NETWORK AND DEPRESSION: A NEUROPSYCHOLOGICAL INTERVENTION BASED fMRI STUDY TO MEASURE THE DYNAMIC FUNCTIONAL CONNECTIVITY

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/05/042450

Enrollment

Registered

2022-05-11

Start date

Unknown

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F32- Major depressive disorder, singleepisode

Interventions

Intervention1: RUMINATION FOCUSSED COGNITIVE BEHAVIOUR THERAPY AND COGNITIVE RETRAINING: Rumination-focused Cognitive Behaviour Therapy was conceived as a manualised Cognitive Behaviour Therapy treatm

experiential and directed imagery exercise to create previous mental states of active thinking styles thereby inducing ‘peak’ experiences

along with behavioral experiments. With its tri-fold focus, one goal is to work on changing habits of rumination, while the others are to work on shifting thinking style and prevent further relapses I

along with behavioral experiments. With its tri-fold focus, one goal is to work on changing habits of rumination, while the others are to work on shifting thinking style and prevent further relapses.

Eligibility

Inclusion criteria

Inclusion criteria: Patients diagnosed as having current depressive episode of mild, moderate and severe without psychotic symptoms, according to ICD-10 criteria and after psychiatric evaluation in the Out Patient Department, Central Institute of Psychiatry. 1. Age range of 18 – 50 years. 2. Both male and female. 3. Patients having minimum educational qualification of 6th pass. 4. Patients who are right handed. 5. Patients who understand English and/or Hindi. 6. Patients with a score greater than 7 on HDRS and greater than 14 on BDI-II. 7. Patients with a score greater than 10 on the rumination response scale-short form. 8. Those who gave informed consent

Exclusion criteria

Exclusion criteria: • Patients with history of co-morbid psychiatric disorders other than depression. • Patients with past history of bipolar episodes. • Patients who fulfilled the criteria for past/present suicidal attempts. • Patients with a history of neurological disorder/ organicity.

Design outcomes

Primary

Measure	Time frame
•Improvement in severity of depression.Timepoint: At Baseline and After 4 weeks of intervention.	—

Secondary

Measure	Time frame
1. Improvement in severity of rumination. 2. Improvement in levels of working memory. 3. Improvement in severity of attentional biasTimepoint: 4weeks	—

Countries

India

Contacts

Public ContactDr PRIYANKA LENKA

CENTRAL INSTITUTE OF PSYCHIATRY

basudeb71@gmail.com9431108544

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026