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The study is about comparing two drugs Dexmedetomidine and Magnesium sulphate with Levobupivacaine in spinal anesthesia for lower limb surgeries

Comparison of efficacy Of intrathecal Dexmedetomidine and Magnesium sulphate as adjuvants to Isobaric levobupivacaine in lower limb orthopaedic surgeries: A prospective randomised double blind clinical study

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/05/042400
Enrollment
60
Registered
2022-05-06
Start date
Unknown
Completion date
Unknown
Last updated
2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Magnesium sulphate with levobupivacaine for spinal anesthesia: Magnesium sulphate 75mg of total 0.5ml with Levobupivacaine isobaric(0.5%) 2.5ml given in spinal anesthesia for lower limb

Sponsors

Government Medical CollegeBaroda
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA grade I,II,III 2.Lower limb orthopedic surgeries 3.Duration of surgery 2.5 to 3 hours

Exclusion criteria

Exclusion criteria: 1.Patient refusal 2.Patient on beta blockers and calcium channel blockers 3.Uncontrolled systemic disease 4.Patient on anti coagulant therapy 5.Pragnant and lactating females 6.Patient with local site infection 7.Patient with allergy to local anesthetics and adjuvants

Design outcomes

Primary

MeasureTime frame
sensory and motor block characteristics 1.onset of sensory block at L1 dermatomal level(min) 2.Time to achieve maximum sensory level(mins) 3.Time for two segment regression(mins) 4.Total duration of sensory block(time to regress till S1 dermatome 5.Onset of motor blockade(Bromage 1)(min) 6.Maximum bromage score(Bromage 3)(mins) 7.Time to achieve maximum motor blockade(mins) 8.duratin of motor blockade(mins)Timepoint: Throught surgery—

Secondary

MeasureTime frame
1.To observe any changes in hemodynamic parameters like pulse rate,blood pressure,respiratory rate,ECG,spo2 perioperatively 2.Duration of effective analgesia-time from administration of drug intrathecally to pain score VAS4 postoperatively 3.Requirment of rescue analgesia in 24 hours 4.To observe any complications like bradycardia,hypotension,respiratory depression,shivering,nausea,vomiting,dryness of mouth,urinary retension etc.Timepoint: Immediate post-op,30 min,1hr,2hr,4hr,8hr,12hr,16hr,20hr,24hr—

Countries

India

Contacts

Public ContactBrahmbhatt Vidhi Narendrakumar

Government Medical college, Vadodara

dr.kashmira13@gmail.com9099045151

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026