Health Condition 1: K852- Alcohol induced acute pancreatitis
Conditions
Interventions
Intervention1: Paracetamol: Patients will be
randomized to receive either injection paracetamol 100 mg/hour infusion or
injection tramadol 100 mg given intravenously at 8-hour intervals for 24 hours
C
Sponsors
AIIMS Bhubaneswar
Eligibility
Inclusion criteria
Inclusion criteria: Patients with AP diagnosed as per the revised Atlanta classification Abdominal pain at enrollment Hospitalization within 7 days of onset of pain Patients who are willing to give consent
Exclusion criteria
Exclusion criteria: Age 75 years Patients with grade 2 organ failure at enrollment as defined by modified Marshall grading Patients with known coronary artery disease Patients in altered sensorium Patients with a serum creatinine > 1.5 mg/dL Patients with evidence of chronic pancreatitis Patients with past history of allergy to tramadol or paracetamol Patients with suspected pancreatic carcinoma Refusal to give consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in the efficacy of paracetamol and tramadol for pain relief was the primary outcome, which was measured by the total dose of pentazocine required as the rescue analgesic, pain-free period, and the total number of demands of the rescue analgesicTimepoint: The study will end at 50 hours, i.e., 2 hours after the last dose of the analgesic | — |
Secondary
| Measure | Time frame |
|---|---|
| Difference in the adverse events between the 2 groups will be the secondary outcomeTimepoint: The study will end at 50 hours, 2 hours after the last dose of the analgesic | — |
Countries
India
Contacts
Public ContactHemanta Kumar Nayak
AIIMS Bhubaneswar
Outcome results
None listed