A clinical trial to study the effect of Ayurveda in patients with duchenne muscular dystrophy

“A Randomized clinical trial to evaluate the efficacy of Ayurveda Interventions as an add on therapy on functional, cardiac autonomic and cortical excitability measures in ambulant patients with Duchenne Muscular Dystrophy (Mamsa medagata vata) ?

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/04/042342

Enrollment

Registered

2022-04-29

Start date

Unknown

Completion date

Unknown

Last updated

2023-08-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G710- Muscular dystrophy

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: Genetically confirmed ambulant patients of Duchenne Muscular Dystrophy (DMD) with elevated serum creatinine kinase Clinical signs consistent with DMD like progressive loss of function delayed walking frequent falls di?culty with running and climbing stairs positive Gower sign and calf pseudohypertrophy

Exclusion criteria

Exclusion criteria: Non-ambulant patients with advanced symptoms of cardiomyopathy and respiratory complications Other muscular dystrophies and myopathies like becker muscular dystrophy, congenital muscular dystrophies - myelopathies, congenital myopathies and metabolic muscle diseases Evidence of any malignancy With contraindications for TMS like major head injury, epilepsy, metallic implants in head and neck areas Patients under steroid medication for a duration of more than six months

Design outcomes

Primary

Measure	Time frame
Functional measures - 6-Minute Walk Test (6MWT), North Star Ambulatory Assessment (NSAA), Timed function tests - Rise from supine, climb four standard stairs, walk/run 10m Ayurveda Rating scales - Vata Rating scale, dehabala pariksha, agnibala pariksha, chetas bala pariksha Timepoint: 2 months	—

Secondary

Measure	Time frame
HRV measures, TMS measures, Echocardiography, Serum Creatinine kinase levels, PedsQL 3.0 DMD Module, Morbidity functional scoreTimepoint: 2 months	—

Countries

India

Contacts

Public ContactDr Kaviraja Udupa

National Institute of Mental Health and Neurosciences NIMHANS

dr.rashmi.ayu@gmail.com9961704592

Outcome results