To evaluate the effect of anti-diabetic drug( Metformin) when using locally for the treatment of gum disease

Comparative evaluation of the efficacy of subgingival metformin in periodontitis-A clinico-microbiological study

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/04/042317

Enrollment

Registered

2022-04-29

Start date

Unknown

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: subgingival local delivery of metformin: Periodontal clinical parameters and Plaque samples will be taken in periodontitis patient scaling and root planing is performed and gelatin base

Eligibility

Inclusion criteria

Inclusion criteria: Systemically healthy subjects. Sites with probing depth (PD) = 5mm. Clinical Attachment Level (CAL) = 4mm.

Exclusion criteria

Exclusion criteria: Patients with any known systemic disease. Known or suspected allergy to the MF/ biguanide group. Patients on systemic MF or other anti-diabetic therapy. Patients with aggressive periodontitis. Use of tobacco in any form. Alcoholism Immunocompromised patients. Pregnant or lactating females

Design outcomes

Primary

Measure	Time frame
plaque scores, clinical attachment level, periodontal probing depth, bleeding on probingTimepoint: Baseline, 3 months	—

Secondary

Measure	Time frame
colony forming unit assesment of subgingival microbiotaTimepoint: baseline, 3months	—

Countries

India

Contacts

Public ContactSUMANTH GUNUPATI

NARAYANA DENTAL COLLEGE AND HOSPITAL

sumant29@gmail.com9848385378

Outcome results