Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium Health Condition 2: O141- Severe pre-eclampsia
Conditions
Interventions
Intervention1: Spinal anesthesia: Doppler Indices like Pulsatality Index, Resistive Index, Peak Ratio of pre spinal anesthesia and post spinal anesthesia will be observed at baseline, post spinal-15 m
Sponsors
PGIMER Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: 1. Control group: 30 Normotensive (age and gestational age matched to cases) pregnant female planned for caesarean section under spinal anaesthesia 2. Study group 2: Severely preeclamptic pregnant females who have received magnesium sulphate planned for caesarean section under spinal anaesthesia Criteria for severe pre-eclampsia 18 Increased bloodpressure (BP; systolic BP is 140 mmHg or a diastolicBP is 90 mmHginawoman who was normotensiveprior to 20 weeks of gestation) accompanied byproteinuria(0.3 g protein in a 24-hour specimen) or increased BPaccompanied by one ormore severe complications of maternal end organ damage evenin the absence of proteinuria like 1. Renal involvement with creatinine > 90 µmol/L 2. Liver involvement with elevatedtransaminases and/or severe right upper quadrant or epigastric pain. 3. Neurological complications like eclampsia, altered mental status, blindness, strokeor more commonly hyperreflexia whenaccompanied by clonus, severe heada-cheswhenaccompanied by hyperreflexia, and persistentvisual scotomata. 4. Hematological complications (thrombocytopenia,disseminated intravascular coa-gulation or hemolysis) 5. Uteroplacental dysfunction (fetal growth restriction)
Exclusion criteria
Exclusion criteria: 1.Patient Refusal 2. Contraindications of spinal anesthesia 3. Short stature 4. Allergy to any drugs used 5. Chronic hypertension, Eclampsia 6. Chronic renal disease, Hyperthyroidism, seizure disorder, noninsulin dependent di-abetes mellitus, severe anemia 7. Twin gestation 8. Autoimmune disorders 9. Presence of ocular injuries or prior ocular surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The change in peak ratio at 15 mins post spinal drug placementTimepoint: Baseline to 15 minutes | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Baseline peak ratio, pulsatility index and resistive index 2. The change in peak ratio after spinal anaesthesia at 30 mins, 60 mins, 120 mins post spinal drug placement. 3. The change in resistive index post spinal drug placement at 15 mins, 30mins, 60mins and 120mins. 4. The change in pulsatility index post spinal drug placement at 15mins, 30mins, 60mins and 120mins. Timepoint: baseline, 15 minutes, 30 minutes , 60 minutes, 120 minutes. | — |
Countries
India
Contacts
Public ContactDr Prerna Varma
PGIMER, Chandigarh.
Outcome results
None listed