Health Condition 1: H050- Acute inflammation of orbit
Conditions
Interventions
Intervention1: Peribulbar injection of amphotericin b: The patients having Rhino-orbital Mucormycosis along with standard of care patient shall receive extraconal inta-orbital local injections of Amph
Sponsors
Guru Teg Bahadur Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Type A - Sub-clinical Rhino-orbital Mucormycosis cases - All cases being admitted at Guru Teg Bahadur Hospital, New Delhi have symptoms of Rhino-Mucormycosis with bony erosion of the (wall/walls) of orbit with orbital fat stranding or others, suggestive of breach of the orbital cavity on contrast-enhanced Computerized tomography. Symptoms of Rhino-Mucormycosis: 1 Nasal stuffiness 2 Foul smell 3 Epistaxis 4 Nasal discharge - mucoid, purulent, blood-tinged or black 5 Nasal mucosal erythema, inflammation, purple or blue discolouration, white ulcer, ischemia, or eschar The cases fulfilling the above criteria shall undergo microbiological confirmation for Mucorales before being recruited into group A. Type B - Early Rhino-orbital Mucormycosis cases- This study shall also include all cases being admitted at Guru Teg Bahadur Hospital, New Delhi having symptoms of early Rhino-orbital Mucormycosis. Definition of early clinical cases: Patients having subtle ocular signs having disease limited to extraconal compartment as seen on imaging. 1 Eyelid, periocular edema 2 Mild ptosis 3 Mild Ocular motility restriction 4 Facial paresthesia, anesthesia (infraorbital) The cases fulfilling the above criteria shall undergo microbiological confirmation for Mucorales before being recruited into group B. Microbiological confirmation - All cases would be confirmed for Mucorales by microbiological direct microscopy of samples drawn from deep nasal swabs or endoscopic guided nasal swabs or nasal biopsy as a part of the standard of care
Exclusion criteria
Exclusion criteria: 1. Rhino-orbital Mucor mycosis patients having intraconal orbital involvement as seen on imaging. 2. Rhino-orbital Mucor mycosis patients having extraconal orbital involvement with best-corrected visual acuity less than 6/6.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Outcome parameters: For group A: Improvement in radiological parameters and non-progression of disease into the intraconal compartment of orbit. For group B: Resolution of disease: Complete improvement in presenting ocular signs in patients having disease limited to extraconal compartment as seen on imaging.Timepoint: Outcome parameters to be assessed daily during intervention and at the end of 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| NATimepoint: NA | — |
Countries
India
Contacts
Public ContactDr Ankur Singh
The University College of Medical Sciences and GTB hospital
Outcome results
None listed