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To determine whether a novel blood test called mi-RNA371a-3p helps in monitoring patients with germ cell tumours

Serial monitoring of micro-RNA-371a-3p in blood among patients with germ cell tumours (GCT): can this guide escalation strategies and treatment course? - None

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/04/042191
Enrollment
60
Registered
2022-04-27
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N448- Other noninflammatory disorders ofthe testis

Interventions

None listed

Sponsors

CMC Vellore
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adult male patients with newly diagnosed testicular germ cell tumour or primary mediastinal germ cell tumour, with no prior chemotherapy

Exclusion criteria

Exclusion criteria: Female patients, any prior chemotherapy, paediatric germ cell tumours, intra cranial germ cell tumours, recurrent germ cell tumours

Design outcomes

Primary

MeasureTime frame
To co-relate circulating mi-RNA 371a-3p with ââ?¬Å?poor prognostic factorsââ?¬? as described by the 2021 IGCCCG update; among both seminoma and NSGCTTimepoint: Long term follow up for 5 years—

Secondary

MeasureTime frame
Correlation between serial AFP/LDH/HCG and circulating micro- RNA-371a-3p levelsTimepoint: Long term follow up for 5 years;CCorrelation between EOT CR; defined as either normal markers and RPLN less than 1cm or absence of residual viable GCT in PC-RPLND histopathology with the baseline and EOT circulating micro- RNA-371a-3p levelsTimepoint: Long term follow up for 5 years;ââ?¬Â¢ Seminoma: Correlation between EOT-PET CT (vs) baseline and EOT circulating micro- RNA-371a-3p levelsTimepoint: Long term follow up for 5 years;Progression free survival (PFS) and Overall Survival (OS)Timepoint: Long term follow up for 5 years—

Countries

India

Contacts

Public ContactAnjana Joel

Christian Medical College, Vellore

anjanajoel@gmail.com09994315798

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026